The present study is carried out with an aim to evaluate the antibacterial and antifungal activities of mixtures of various zeolite derivatives viz. Propolis-Zeolite, Silver sulfadiazine - zeolite and silver - zeolite. The antimicrobial activity of mixtures varying proportions were tested against two gram +ve bacteria: Staphylococcus aurens, Streptococcus pyogenes, and two gram –ve bacteria, Escherichia coli, Pseudomonas aeruginosa (Common pathogenic) bacteria and six fungal strains Penicillium, Rhizopus, Mucor fungal strain, Aspergillus niger, Aspergillus flavus and Candida albicans. All the activities were determined by using agar disk diffusion method. The zone of inhibition of growth of microbes were compared with the standard drug. The results show the remarkable inhibition of growth of bacteria in comparison to individual zeolite derivatives, hence present mixture of derivatives may be potentially used to develop new pharmaceutical products.