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ISSN 2063-5346
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STUDIES ON TRANSITION METAL COMPLEXES OF DRUG BASED SCHIFF BASES

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Kirti Salame, Arun Singh
» doi: 10.31838/ecb/2023.12.4.176

Abstract

The Isoniazide (IZ) reacted with 5-Chlorosalicyladehyde (CSA) and 3,5-dichloro salicylaldehyde (DCSA) yields novel ligands, N'-(5-chloro-2-hydroxy benzylidene) isonicotinohydrazide (CSAIZ) and N'-(3,5- dichloro-2-hydroxy benzylidene) isonicotino hydrazide (DCSAIZ). The transition metal chelates of CSAIZ and DCSAIZ ligands were prepared by using Cu2+, Co2+, Ni2+, Mn2+ and Zn2+ metal ions. All the CSAIZ and DCSAIZ ligands and its all metal chelates were characterized by elemental content, IR spectroscopic, metal: ligand ratio and magnetic properties. All the CSAIZ and DCSAIZ ligands and its all metal chelates also were monitored for antimicrobial activity.

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