Cytogenetic and molecular cytogenetic characteristics have been studied in 200 patients with fertility problems. Chromosome analysis has been performed by GTG banding on the cultures of peripheral blood lymphocyte The purpose of the present study was to investigate the contribution of chromosomal anomalies and the frequency of a particular type of aberration in couples with recurrent miscarriages. First trimester pregnancy loss is a very common complication and a matter of concern for couples planning pregnancy. Balanced chromosomal rearrangements in either parent is an important cause of recurrent pregnancy loss particularly in the first trimester of pregnancy. Chromosomal analysis is an important etiological investigation in couples with repeated spontaneous abortions as it helps in genetic counseling and deciding about further reproductive options. We believe that the patients with chromosomal anomalies in the karyotype need differentiated treatment.