Background: Acne vulgaris is common skin disorder encountered in skin outpatient department in day to day practice. Acne can cause psychological distress, low self-esteem, and social withdrawal, affecting quality of life as much as more physically disabling diseases such as asthma and diabetes. Drug used in dermatological problems especially in acne are one of the top selling drugs in India however they are least studied with respect to drug utilization. Present study was undertaken to analyze drug utilization in various prescriptions at OPD & IPD of Department of Dermatology of Integral Institute of Medical Sciences and Research. Methods: A prospective, cross-sectional, non-experimental (observational) study was performed in IPD & OPD of dermatology department of Integral Institute of Medical Sciences and Research over a period of 6 months. During the study a total of 100 prescriptions were analyzed. The patient demographic details like name, age, sex, place, and weight were noted in specially designed patient documentation form. Diagnosis, patient complaints, number of drug prescribed, social history, generic name, brand name, were recorded daily in patient data collection form. From the prescriptions the drug interactions were identified by using drug interaction checker and micromedex software. Results: Among 100 patients it was observed that maximum no of ptients were females (58%). Highset no of patients were from age group 21-25 years of age. Grade II (52. %) consists of the majority of cases while others are Grade I (35.%), Grade III (10%) and Grade IV (3 %) Conclusions: In present study percentage of drugs prescribed from national essential medicines list (NLEM) was found to be satisfactory but shows use of branded (Non-Generic) drugs. Drug utilization studies have the power to make objective evaluation as well as analysis of prescribers work and help them by giving feedback about their way of practice. This will help to determine and employ rational use of drugs among population. This study helps to give feedback to the treating doctors, by improving patient care by the way of rational prescribing of drugs.