This research studies how altitude affects gasoline-powered light-duty vehicles by observing their fuel consumption and emissions through different driving cycles designed to represent different areas of Latin America. To carry out this study, four years of light-duty vehicle operating data were collected over a wide altitudinal range in Ecuador, and the most reliable data were selected. Then, various methodologies were used to construct driving cycles based on micro-trips, which were randomly selected to prioritize the most repetitive operating conditions.