Due to common risk factors including smoking, patients with COPD often also suffer from coronary artery disease (CAD). Previous research has shown that patients with COPD who have CABG have a higher risk of mortality and complications. Between 8 to 20 percent of the population has chronic obstructive pulmonary disease (COPD), and moderate COPD is linked to greater cardiovascular mortality rates than respiratory insufficiency. Aim: To find Better management of patients with mild to moderate symptomatic COPD and those without COPD undergoing (CABG) and to improve post-operative outcome. Methods: This study was conducted at Cardiothoracic Surgery Department, Zagazig University Hospitals. The study included 48 patients who underwent coronary artery bypass grafting with mild to moderate symptomatic COPD and without Chronic obstructive pulmonary disease subdivided into two groups. Results: All Lung volume measurements were significantly increased in COPD patients. PaO2, and PH were significantly decreased in COPD patients. PaCo2 was significantly increased in COPD patients. There was a significant increase in CPB time and Aortic Cross-Clamping in COPD patients. Mechanical ventilation time, ICU time and total time of hospital stay were significantly increased in COPD patients. Conclusion: Our study highlights the impact of COPD on early morbidity and mortality post CABG. Patients with COPD who undergo CABG surgery experience a longer duration of mechanical ventilation, ICU stay, and total hospital stay, as well as a higher incidence of atelectasis, which may be attributed to the impaired lung function and reduced respiratory capacity observed in these patients.