Nephrotic syndrome (NS) in children is a disease with edema, proteinuria, hypoalbuminemia and hyperlipidemia. Due to decreased immunity, chances of infections are very high in NS and these infections may be important causes of morbidity and mortality in NS. This study was done to observe the infection pattern in NS and to identify the responsible organism. This may help in further management of the disease. Material and methods: This study is a hospital based, cross-sectional, descriptive study conducted between July 2022 to June 2023, in a tertiary care centre. A total of 132 nephrotic synndrome children were enrolled after applying exclusion criteria. Socio-demographic history was taken and different investigations were followed to screen for infection. The data was entered in SPSS (software version 20 and analyzed. Results: In this study more than half (53.3%) of the patients were male and rest were female with overall mean age of 6.26±2.05 years. 69.2% of children were having initial attack of nephrotic syndrome while 30.8% were relapse cases. UTI with maximum occurance of 40% followed by pneumonia and peritonitis were found to be the most common infection in children with nephrotic syndrome and E. coli was the most common organism isolated from infected cases. Conclusion: Screening for infection in children with nephrotic syndrome plays an important role for early detection of any infection. Pattern of infection may vary in different geographical areas.