One of the biggest factors preventing the use of antidepressants is their negative effects, one of which is sexual dysfunction. The patient's quality of life is negatively impacted by this problem, which may increase clinical non-adherence in long-term therapy. The aim of the current study was to study the characteristics of sexual dysfunction in married female patients on antidepressants. Methodology: The study comprised 98 adult female patients over the age of 18 who went to the Psychiatry OPD between August 2021 and July 2022. A standardised questionnaire was used during an interview with them to elicit the adverse effects both before and after commencing antidepressants. Results: In the current study, 71% of females has experienced sexual dysfunction brought on by antidepressants. The means and standard deviation values of the Pleasure, Desire/frequency, Desire/interest, Arousal, and Orgasm scores are found to be statistically significant. Conclusion: Sexual dysfunction is found to be very common in married female patients who are on antidepressant medications across all the domains