Background: Management of acute ischemic stroke (AIS) can be more apt if timely diagnosis and proper assessment of prognosis are performed. The study aimed to evaluate the risk factors of acute ischemic stroke and assess prognostic role of the neutrophil to lymphocyte ratio (NLR) in acute ischemic stroke patients. Materials and methods: This was a single-centre, hospital-based, observational, descriptive study which included patients with AIS who were admitted in the this hospital over a period of 18 months. Clinical history of the patient such as severity of stroke during admission and the outcome of their health was collected in the database. The NLR was calculated from the blood sample collected at the time of admission. Further, the NLR was evaluated in relation to each risk factor and the significance of association with them was evaluated.