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ISSN 2063-5346
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Study of Single Nucleotide Polymorphism of Interleukin 1 B in Pediatric Patients with Health Care Associated Sepsis

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1Abdelrahaman Eid Mahmoud Mossad, 2Maysaa El Sayed Zaki, 2Emad Ibrahim Mohammed Elmasry, 3Ahmed Gomaa Ahmed El Sayed, 1Dina Mohamed Abdel- Hady
» doi: 10.48047/ecb/2023.12.10.214

Abstract

Background: Health care associated sepsis in children is a global health problem. Predisposing to this infection may include single nucleotide polymorphism (SNP) in interleukin 1 β gene (IL1 β). Objective: the aim was to study the association of L-1β +3954 C>T polymorphism in children with health care-associated sepsis. Method: The study is a retrograde case-control study that included ninety two children with hospital-acquired sepsis and ninety two children as control group. Blood samples from included children were subjected to blood culture for identification of sepsis and SNP study of IL1 β by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).

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