The use of botanicals in pest management is not only useful for suppression of pest population but also helps to maintain the sound ecological balance. Tulsi (Ocimum sanctum) is an aromatic plant in the Lamiaceae family. It has been used for thousands of years in Ayurveda due to its diverse healing properties. In conclusion it can be stated that it was effective significantly at different concentrations. The botanicals used in this study such as Ocimum sanctum were showed different levels of insecticidal activities. These findings of the present study suggest that Ocimum sanctum extract can be used as a botanical spray to get better and safe control of mealybug P.solenopsis. The present work deals with selection of suitable herbs with a maximum mortality rate of scale insects. This could go a long way in controlling adult females to prevent further production of eggs in consecutive generations. Since phytochemicals are safe, easily available round the year and cost effective, these stimulate local efforts to enhance the magnitude of pest control. Such an effective formulation can be used for large scale field study by agriculturists to decimate scale insect menace during flowering and fruition. The research has shown that insecticides made from natural botanical source such as tulsi leaves for mealybug eradication are less toxic as compared to those from the synthetic origin hence it is safer to use insecticides prepared from natural raw materials since they have little or no adverse effects on human health.