In this work, the kinetics of the reaction of obtaining high-molecular hydrocarbons from synthesis gas was studied. In the first series of experiments, the initially activated catalyst 15%Co-15%Fe-5%Ni-1%ZrO2-1%CaO/y-Al2O3 was developed in synthesis gas with the composition CO/H2=1/2 at a pressure of 0.1 MPa, space velocity 100 h-1. The temperature was raised from 150 to 190°C in increments of 10°C. The duration of daily operation at each temperature was 5 hours. At a temperature of 190°C, the volumetric rate of synthesis gas transfer increased from 400 to 500 h-1. The calculated values of E for various gas transfer volumetric rates and the calculated average values of k for each temperature are given. The root-mean-square error in the calculation of the activation energy is 3.19%. At a temperature of 180°C, the average value of the rate constant is 4.52 h-1 with a standard deviation of 8.56%. The activation energy of the reaction at 190 and 200°С can be calculated from two values of the rate constant. It is 89.31 kJ/mol