Background: Insulin resistance (IR) is a primary component of metabolic syndrome (MetS), a collection of disorders related to metabolism. Recently, there has been discussion on the potential link between MetS and its constituent parts and changes in the morphology and function of the thyroid gland. Owing to the elevated morbidity rate associated with TNs and enlarged thyroid, research on the disease's risk factors is necessary. Aim: To determine the effect of components of the metabolic syndrome as causes of increased thyroid volume. Methods: This study was conducted at Internal Medicine Department, Faculty of Medicine, Zagazig University on 32 patients with metabolic syndrome who were divided into 20 patients with enlarged throid volume and 12 patients without enlarged thyroid volume. Thyroid profile and ultrasound were measured. Results: The prevalence of enlarged thyroid volume among patients diagnosed with MetS was (62.5%). There was significant increase in TSH, anti TPO and anti-thyroglobulin in enlarged thyroid group than normal volume thyroid group Conclusion: Our findings revealed a high prevalence of enlarged thyroid volume (62.5%) among patients diagnosed with MetS. Our findings suggest a potential link between MetS and enlarged thyroid with possible underlying mechanisms such as metabolic dysregulation.