The emerging trends of antibiotic resistance in widely implicated pathogens exacerbate the already high risk of bacterial infections in cancer patients. Specifically, gram-negative bacilli including E. coli, Klebsiella pneumoniae, and Acinetobacter spp. provide a greater challenge in the Indian context. It is especially worrisome because resistance is on the rise among grampositive bacteria. The goal of this study was to keep track of the most common bacteria that cause infections in cancer patients and to describe how well antibiotics work against them.