Menstrual hygiene in India has become synonymous with disposable sanitary pads and these products are considered as the most hygienic and safest option. The main role of sanitary napkins is to absorb menstrual blood and to maintain a standard level of hygiene. A comparative efficacy and safety performance of product included four - disposable non compostable menstrual pads, one disposable compostable, one reusable compostable, and one reusable non-compostable product widely available in India. The efficacy studies included - total absorption property such as absorption capacity, retention capacity, wetback properties and absorption rate at different volumes. Safety study included the biocompatibility by cell viability testing in L929cells. The absorption capacity of pads depends on the dimensions of the sanitary napkins. The total absorption property of sanitary pads were evaluated by studying maximum fluid (NS/B) absorbed or absorption capacity, retention capacity or the amount of fluid retained after applying pressure and the fluid lost from the pads on the application of pressure as wetback capacity. Prolonged exposure of sanitary pads to blood simultaneously transforms into a breeding zone of pathogens which can further cause major health concerns in women. The L929 cells are highly preferred to study cytotoxicity. These are mouse fibroblast cells. Cell viability or cytotoxicity assay are designed to evaluate the general toxicity of materials or medical devices. Testing involves extracting materials and then exposing the extract fluid to mouse fibroblast cells (L929). The cells are allowed to grow in cell media with different concentration of the extracts for a specified amount of time. These tests are generally performed on medical devices or personal care products and its raw material to identify any possible underlying toxicological risk. The results showed that all these products had varied level of efficacy and safety properties when exposed to normal saline or blood. Study finding suggests that there is a potential risk for women using disposable sanitary pads. When pads are exposed for longer durations, women experience rashes and irritability. Users of pads are constantly at risk for allergies, which may be brought on by the chemicals in them. The continuous use of these pads can cause fungal infections, reproductive tract infection, UTI etc. Majority of these concerns arise only when a female is exposed to sanitary pads for prolonged hours thereby indicating poor menstrual hygiene. Regulation needs to be mandatory in testing these products like class 1 medical devices as these products are exposed to vaginal tissue or mucosal layer and can impact the health of women.