Muscle cramps are often experienced by the patients on hemodialysis that result in discomfort, shortened treatment times, and inadequate dialysis dose. Up to 50% people with chronic renal failure undergoing dialysis suffer from muscle cramps, especially involving the lower limbs. The cramps can happen during dialysis or at home. The cramps in this type of patient are linked to depression, a decline in quality of life, and sleep disorders. The etiology of cramps in hemodialysis patients is not clear.