The study aimed to assess the Immunomodulatory activity of the tuberous root of Kshirvidari (Ipomoea digitata Linn.) Kwath (decoction) and Churna (powder) in experimental animals by following standard procedure. Randomly selected mice were divided into five groups of six animals each. The root of Ipomoea digitata Linn.) was administered orally in the form of Kwath and Churna. Parameters like Haemoglobin, RBC count, WBC count, DLC, Platelet count, and measurement of Paw thickness were studied. Kwath (10.4 ml/kg) and Churna (1300mg/kg) of Kshirvidari showed significant improvement in paw volume. From the present study, it can be concluded that the root of Kshirvidari has Immunomodulatory activity.