Rheumatoid Arthritis is a long-term inflammatory systemic autoimmune disorder that shows its effect on symmetrical joints as well as other body organs. Mostly, women are susceptible to the rheumatic disorder as compared to opposite sex, which is depicted as in ratio 3:1. There are two subtypes of RA out of which ACPA-positive is found in 67% of the patients as compared to the other and also, the effect of drugs is more in positive type than other. The treatment plan targets the reduction in the inflammation, pain and decelerate the damage of the joints, as the RA is non- curable in modern era. The treatment of the RA has undergone remarkable conversion since decades and now it is treated with the strategy known as treat to target. The Anti-Rheumatic drugs, such as DMARD’s, corticosteroids etc. are classified and prescribed according to the symptoms of the patient. The treatment of RA of prescribing drugs should be according to the guidelines (national essential list of drugs, WHO guidelines etc.) or on the basis of patient symptoms. (DOI: 10.3892/etm.2016.3045) Hence, we scrutinize the treatment for controlling the symptom of RA in patients.