Research has aided the healthcare professionals with an improved understanding of the link between domestic violence and substance abuse. However, under-reporting of domestic violence still persists due to societal stigma. This presents an opportunity to enhance care and address the impact on individuals and their families. Comprehensive interventions are needed to address domestic violence and substance abuse, preventing further harm and long-term health issues. Substance abuse, stress, and mental illness can intensify domestic violence. If unaddressed, nonphysical abuse can escalate to physical violence and have severe consequences. Addressing domestic violence in healthcare requires specialized approaches to overcome unique challenges. Despite stringent laws and well-established legal enforcement agencies, reporting remains low. Challenges in enforcing domestic violence laws also include police apathy and insufficient personnel, leading to inadequate investigation and documentation. The research utilizes a narrative approach, reviewing relevant literature without a formal systematic process. A meta-synthesis technique has been employed to combine and interpret findings from qualitative research studies. This approach provides relevant findings and credible recommendations based on a comprehensive review of past literature. This study identifies key issues and limitations, and provide recommendations for practice, policy, and future research.