In recent times there are many advances in surgeries and wound healings. Surgical Glue (SG) plays a vital role in healing of wounds with their various effective properties and actions. Wound healing is an important step of surgeries for a human body. This works for wound closure by the principle of bio-adhesion which also leads to the reduction of risk in patient's health care in case of side effects of anesthesia. Many advantages of SG which is also known as tissue adhesive (TA) exists over sutures and staples. SG works by bonding the edges of the wound together, sealing it and allowing it to heal without the need for traditional sutures or staples. The evidence indicates that TA help in reduction of time for wound closure effectively. There are myriad patents issued by legal authorities all over the world. SGs are used in numerous surgeries such as neurosurgery, orthopedic aciurgy, periodontal aciurgy, urology, reconstructive and plastic aciurgy, ophthalmic aciurgy, pneumothoracic aciurgy, gastrointestinal aciurgy and cardiovascular aciurgy.