INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory disorder of autoimmune origin that may affect many tissues and organs but principally attacks the joints. Analysis of pannus tissues in RA patients discloses characters of transmuted cells living for longer duration with, apoptotic tolerance, oncogenes expression and somatic mutations. Survivin belongs to the Inhibitory Apoptotic Protein family which is suggested to play a role in the pathogenesis of RA, and is recently emerging as a biomarker for Rheumatoid Arthritis. AIMS AND OBJECTIVES: The objectives of this study were to estimate and compare the salivary survivin concentration with serum survivin concentration and to correlate with the treatment.