The synthesis of ferrocene-functionalized heterocyclic compounds remains a dynamic area of research, yet documentation regarding the creation of ferrocene-functionalized 2-aminopyrimidines is conspicuously absent within existing literature. Addressing this gap, our study presents a pioneering approach to generate a novel class of compounds, specifically 2-amino-4-aryl-6-ferrocenyl pyrimidines, catalyzed by Sodium alkylbenzene sulfonate in an aqueous medium. Our methodology involves a base-induced condensation process, employing a diverse array of 3-aryl-1-ferrocenyl-2-propen-1-ones, commonly referred to as ferrocenyl chalcones, in conjunction with guanidine hydrochloride. The use of Sodium alkylbenzene sulfonate surfactant as a catalyst facilitates this synthesis, operating within an aqueous environment to ensure both sustainability and efficiency. This work not only expands the scope of ferrocene-based heterocyclic chemistry but also underscores the potential for further exploration and utilization of these newly synthesized compounds across various scientific domains. The demonstrated synthetic pathway, catalytic approach, and compound characterization herein provide a foundational framework for future investigations into ferrocene-functionalized 2-aminopyrimidines, stimulating continued research interest in this burgeoning field.