“A set of six 2-[(E)-2-substituted-ethenyl]-1,3-benzoxazoles was synthesized and characterized”. Three types of mycobacteria were used to test all of the compounds that were made. “2-[4-(methylsulfanyl) phenyl] ethenyl-1,3-benzoxazole was the most effective against M. tuberculosis, M. avium, and M. kansasii”. It was also much more effective than isoniazid against M. avium as well as M. kansasii. “The most powerful ortho-substituted compound, 2-[(E)-2-(2-methoxyphenyl) ethenyl]”, is able to stop PET from working. The relationships between structure and action are also talked about.