Reaction and condensation between 2-chloroquinoline-3-carbaldehyde and substituted coumarone to Produced chalcone, the derivative (3) was adopted as chalcone to react with different compound such as ethyl cyanoacetate, ammonia, urea, thiourea, phenylthiosemicarbazide, and hydroxyl amine hydrochloride to produced new ring of pyranone, pyridine, pyrimidine, pyrazole and isoxazole compounds (4,5,6,7,8,9) respectively, were identified their structure by infrared spectroscopy, Nuclear magnetic and elemental analysis. Pharmaceutical applications have been studied for the prepared compound and achievement with different drugs.