The sincere effort of man to control and cure diseases has implied in the search of new drugs. The synthesis of derivatives has been an important part of research in medicinal chemistry. Medicinal chemistry is the science that deals with the discovery and design of new therapeutic chemicals and their development into useful medicines to treat diseases. Medicinal chemistry involves isolation of compounds from nature or synthesis of new molecules  investigation of the relationships between the structure of natural and/or synthesized compounds and their biological activities elucidations of their interactions with receptors of various kinds including enzymes and DNA determination of their absorption, transport, and distribution properties and studies of the metabolic transformations of these chemicals into other chemicals and their excretion. Drug discovery research is a highly creative and stimulating work environment where people are driven to succeed by personal and scientific objectives as well as with the desire to contribute to society’s well-being. In the past, most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery for the creation of new synthetic drug compounds. Medicinal chemistry is almost always geared towards drug discovery and development. A new approach has been developed to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge.