.
-
BIOCHEMISTRY OF FASTING – A REVIEW ON METABOLIC SWITCH AND AUTOPHAGY.
Volume - 13 | Issue-1
-
ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL
Volume - 13 | Issue-1
-
MODELING AND ANALYSIS OF MEDIA INFLUENCE OF INFORMATION DIFFUSION ON THE SPREAD OF CORONA VIRUS PANDEMIC DISEASE (COVID-19)
Volume - 13 | Issue-1
-
INCIDENCE OF HISTOPATHOLOGICAL FINDINGS IN APPENDECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL IN TWO-YEAR TIME
Volume - 13 | Issue-1
-
SEVERITY OF URINARY TRACT INFECTION SYMPTOMS AND THE ANTIBIOTIC RESISTANCE IN A TERTIARY CARE CENTRE IN PAKISTAN
Volume - 13 | Issue-1
Synthesis and biological evaluation of novel 1,3,4-thiadiazole-linked indole derivatives as potential antimicrobial agents
Main Article Content
Abstract
The synthesis of some 2-phenyl-5-substituted-1, 3, 4-thiadiazol derivatives are synthesized and evaluated for antibacterial and antifungal activity. All the new compounds structures were elucidated by IR, 1HNMR, and MASS spectral data. Antibacterial activity of all compounds was evaluated against Bacillus subtilis, Bacillus megaterium, Escherichia coli and Pseudomonas Species and antifungal activity was evaluated against Candida albicans. Study revealed that Compound 9f showed potent activity against Bacillus subtilis and Bacillus megaterium with MIC 6.8 and 7.4µg/mL respectively. Compound 9e showed potent activity against Escherichia coli with MIC 2.2 µg/mL. Compound 7i showed potent activity against Pseudomonas species with 1.8µg/mL. Compound 9i showed potent antifungal activity against Candida albicans with MIC 6.4µg/mL.
Article Details
