In the recent work, we synthesized derivatives of chalcone from pyrazole aldehyde. In additionwe prepared chromone from chalcone derivatives.Herewe performed simple condensation reaction between acetophenone with novel pyrazole aldehyde to yield chalcone. further we synthesize chromone from chalcone. A series of chalcone and their chromone derivatives were successfully achieved with good yield. All the synthesized compounds are characterized and confirmed by spectral analysis like 1H NMR, 13CNMR, IR & Mass. Further synthesized derivatives were studied for biological screening