Benzoxazole derivatives are very useful compounds with well-known biological activity and has promising activity as therapeutic agents. In the current research work, the twelve benzoxazole derivatives 3a-l were synthesized by the cyclocondensation reaction of appropriate carboxylic acid with 2-amino phenol in POCl3. All the synthesized benzoxazole derivatives were confirmed structurally by means of IR, 1H NMR, 13C NMR and Mass spectral analysis.