In this study, the synthesis of silver nanoparticles is reported from Ipomoea palmata leaf extract. The AgNPs were characterized using a UV-Visible spectrophotometer, XRD, FTIR, and FESEM with EDS. A peak at 439nm of Surface Plasmon Resonance was observed at UV-Vis. The crystalline nature face cubic centered was confirmed by XRD and the 2ϴ value was 28.0,32.4, 44.1, 46.5, 54.9, 57.7, and 76.8 corresponding to planes 122, 111, 200, 200, 220, 220 and 311. FTIR analysis spectral peaks were observed at 3293.18, 2350, 2092.47, 1624.83, 388.16, 1108.30, 70.82, 580.86 responsible for the biomolecules OH, C-O, C=C, C=C, N-O, and C-X (Floroalkane, Chloroalkane and Bromoalkane) respectively. FESEM analysis showed that the particles are spherical in shape with size varying between 12-25 nm and the average size was 18 nm.