Natural compounds are increasingly being used in organic synthesis due to their environmental safety. That is why we identified a natural material that enhanced the organic reaction, and it could be sustainable and obtained from plant sources, and it stimulates the synthesis of dihydropyridine and its derivatives under solvent-free circumstances through this natural substance. We used this process to synthesise highly functional dihydropyridine derivatives since it is cost-effective and free of minerals and solvents. It is encouraged by dragon fruit water extract (WED) at a temperature of (80 0C). These (WED) promoted reactions have been discovered to provide a high yield for the target compounds, and this method is Protocol an option to the present procedures.