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ISSN 2063-5346
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Synthesis, characterisation and pharmacological studies of ferrous (II), cobalt (II), nickel (II), palladium (II), manganese (II) and copper (II) complexes of pyrrolo pyrimidine derivatives

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Abhay Bagul, Digamber Gaikwad, Yogesh Patil, Nilesh Bhusari
» doi: 10.48047/ecb/2023.12.si7.123

Abstract

The structure's M (II) complexes [ML2] have been synthesized using a Schiff base from 4-chlorobenzaldehyde and pyrrolopyrimidinehydrazide. According to the metal content analysis, a new series of Fe(II), Pd(III), Mn(II), Co(II), Ni(II), Cu(II), and Mn(II) metal complexes are created with a 2:1 ligand: metal ratio. The metallic ion is coordinated by nitrogen atoms from the azomethine, pyrrolo, and pyrimidine rings. The Fourier Transform-Infra Red (FT-IR), Ultraviolet-Visible Spectra (UV-Vis Spectra), 1H-Proton, and 13-Carbon Nuclear Magnetic Resonance (for the ligand), ESR, Magnetic Susceptibility at 25 °C, and Conductivity measurements have all been used to infer the stereochemistry of the ligand complexes. The conductivity measurements demonstrate the metal complexes' non-electrolytic behavior. Notwithstanding the possible exception of the Pd(II) complex, which has a square planar geometric structure, electronic spectra analysis research demonstrated that all complexes have an octahedral structure. Magnetic moment and conductance studies supported this research. The Minimum Inhibitory Concentration approach was used to test the antibacterial and antifungal effects of the Schiff bases and their metal complexes on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and B. subtilis.

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