The trimethoprem drug was condensed with tetrahyrothalic anhydride. The resultant Bis tetrahydrophalamic acid of trimetroprem namely; 2, 4-Bis (5-carboxycyclone hex -1-en-6carbomyl)-(3, 4, 5-trimethoxyphenyl) methyl pyrimidine, characterised duly. The coordination polymers of this bis ligand were BTPT prepared by using metal ions viz; Cu+2, CO+2, Ni+2, Mn+2, and Zn+2. The coordination polymers and parent ligand BTPT were analysed by metal: ligand ratio, spectral features, magnetic moment, large molecular weight and thermogravimetry. The antimicrobial activity of all the Mn- ligands and polymers were evaluated by Agar-cup-method.