Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
The3-(6-(5-substitutedfuran-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-yl)-2H-chromen-2-one1(a-e) reacted with hydrazine hydrate to form 3-(6-(5-substituted furan-2-yl)-2-hydrazinyl-1,4-dihydropyrimidin-4-yl)-2H-chromen-2-one 2(a-e). The compounds 2(a-e) then reacted respectively with formic acid and acetic anhydride yielded 3-(5-(5-substitutedfuran-2-yl)-7,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-7-yl)-2H chromen -2-one 3 (a-e) and 3-(5-(5-substituted furan-2-yl)-3-methyl-7,8-dihydro-[1,2,4]triazolo [4,3-a] pyrimidin-7-yl)-2H-chromen-2-one 4(a-e). All the Synthesized compounds were characterized by elemental analysis, 1H NMR, IR and LC-MS spectral studies. Antibacterial activity of all the compounds was studied against gram positive and gram negative bacteria and antifungal activity of all the compounds was studied against various fungi.