3-chloro-4-(substitutedphenyl)-1-(5,5,7-trimethyl-3a,4,5,6,7,7a-hexahydrobenzo[d]thiazol-2-yl) azetidin-2-one 3(a-d) and 2(a-d) were prepared by systematic route. Compound (1) 5,5,7-trimethyl-3a,4,5,6,7,7a-hexahydrobenzo [d] thiazol-2-amine was prepared by reaction between 5,5,7 tri methyl cyclohexanone reagent (AR. Grade Aldrich) batch 2020 and with thiourea. Compounds 2(a- d) N Substituted benzylidine 5, 5, 7 tri methyl 3a, 4, 5, 6, 7,7a hexahydrobenzo (d) thiazol- 2 amine) were prepared from (1) compound and different derivatives of aromatic aldehyde, then compounds 3(a-d) were synthesis from derivatives of 2(a-d). Synthesis of compounds 3(a-d) showed better valuable characteristic and efficacy as antifungal. In these compounds chloro and hydroxyl azetidinone derivatives showed better inhibition nature as compared to standard drugs and less side effect. Other derivatives of azetidinone also showed the proper affectivity. A new class of 3(a-d) series of azetidinone nucleuses possess better biological property (antifungal properties) and in medicinal chemistry. The structure of new synthesised compounds was identify and confirmed elemental analysis by, IR, NMR, and their properties were screened as antifungal activity. Purity of synthesised derivatives of azetidinone was checked with the help of TLC.