An analysis of the biological effects of flavanols revealed that although several natural 3-flavonols were used to treat conditions like inflammation, neither their synthetic derivatives nor information on natural 7-flavonols had been documented up to this point. The Phyto flavanols must also undergo a challenging and time-consuming process to generate, standardize, validate, and, if necessary, undergo chemical transfusion. Using an efficient method, diverse 3-formyl, 7-flavonols, and thiazolidinediones were converted into the compounds of various 2", 4"- thiazolidinedione derivatives of 7-flavonols through a technique MEC. Although different nitro- and acetyl-derivatives of flavanols have not yet been synthesized, under microwave circumstances, the reactions for both substituents on position 7 of the benzene ring A of the flavone ring performed well, and the analytical results were good. Through the use of Co-TLC, max, IR, HPTLC, 1HNMR, CHN analysis, and mass spectral studies, the re-crystallized products were identified. The fingerprint profiles produced by HPTLC differed from those produced by a standard Co-TLC approach in that they had a single conspicuous peak and matched Rf values. Using the in vitro protein denaturation technique and the in vivo paw edema model, all the produced compounds were evaluated for their ability to reduce inflammation The results showed that all compounds, except the unsubstituted 2', 4' -thiazolidinedione derivatives of 7-flavonols, produced an equal amount of or more powerful action as the standard.