This review looks at the synthesis, DNA-restricting, and organic appraisal of benzimidazole Schiff base ligands and their metal(II) buildings. The combination of these blends includes the response of an aldehyde or ketone with an amine or amino corrosive within the sight of a dissolvable, trailed by the expansion of a metal salt. The portrayal of the mixtures is commonly done utilizing strategies like infrared spectroscopy, UV-Vis spectroscopy, and essential examination. The DNA-restricting limit of these mixtures is concentrated on utilizing strategies like UV-Vis spectroscopy, fluorescence spectroscopy, and round dichroism. The organic assessment of the mixtures incorporates testing their antimicrobial, anticancer, and different exercises. The outcomes have shown that these mixtures have possible applications in the fields of helpful science, materials science, and catalysis. Future examinations ought to zero in on investigating the capability of these mixtures in other remedial regions and streamlining their construction for improved bioactivity and particularity.