Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Thiazoles and triazole derivatives are well known for their biological activities and their application in the field of medicine. In this paper synthesis of fused heterobicyclic system containing thiazole and triazole has been reported. Taking 2-chloro-4-aryl-1,3-thiazole as precursor and successive reaction with hydrazine followed by reaction with ethyl chloroacetate and then cyclization step resulted in formation of thiazolotriazolone derivatives namely 5-aryl[1,3]thiazolo[2,3-c][1,2,4]triazol-3(2H)-one derivatives. Synthesized compounds were characterized by spectral analysis. Computational studies have been utilized to evaluate physicochemical and Pharmacokinetic (ADMET) properties using pkCSM online tool. SWISS ADME online server has been used for prediction of Physicochemical properties and Rule-based filters for Druglikeness.