Grafting of acrylic acid onto potato starch in aqueous medium initiated by diode laser has been studied under N2 gas. The optimum conditions with respect to monomer concentration (acrylic acid AA), initiator concentration, graft copolymerization temperature, graft copolymerization time and exposure time of diode laser were studied in terms of percentage grafting efficiency (%GE) and percentage grafting yield (%GY). Potato starch-g-AA graft copolymer was characterized by FTIR, TGA for thermal stability, x-ray diffraction (XRD) for their crystallinity and scanning electron microscope (SEM) for surface morphology. The graft copolymer will be later used in drug delivery carrier to control cancer in brain and matrices for colon aiming medicine delivery systems. This study focused to new trends and latest developments in this area where diode laser was found to be efficient and clean method for synthesis Potato starch-g-AA.