This study investigates the synthesis, anti-inflammatory efficacy, and safety profile of heterocyclic derivatives based on indoles as possible new treatments for disorders associated with inflammation. Through structure-activity relationship investigations, we give a thorough examination of the chemical changes and their effect on anti-inflammatory efficacy. Evaluations conducted in vitro show the compounds' capacity to control important inflammatory pathways and decrease pro-inflammatory mediators. Their effectiveness in reducing inflammation in animal models is demonstrated by in vivo investigations. Assessments of their toxicity also provide information on their security and potential negative consequences. In contrast to currently available medications, heterocyclic derivatives based on indoles show promise of anti-inflammatory effectiveness with the potential for increased selectivity and new modes of action. Although there are still difficulties with clinical translation, their potential as potent anti-inflammatory drugs calls for more research and development.