A number of 3- amino methylene- [2'-(2"- substitutedbenzyliden-4"- thiazolidin-3"-yl)-1',2',3',- thiadiazol-5'- yl] benzopyrone(7 and its derivative) was synthesized through the interaction of the mercapto acetic acid and anhydrous zinc dichloride with 3 amino methylene [2'-(substituted benzylidene)-5'-yl] amino benzopyrone (6 and its derivative) and compound (6) was formed by reaction of compound 5 i.e. 3 Amino methylene- (2 amino-1,3,4 thiadiazol-5-yr-benzopyrone with different aldehydes respectively. In mixing of oil of vitriol(H2SO4) with 3- Amino-2-benzopyrone acetyl thio semi corbazide substance 5 has been created. Elemental analyses and spectrum research were used to establish the compounds' structures. The effectiveness of the newly created compounds as antifungal agents against Aspergillus flavus, Aspergillus niger, and Aspergillus fumigatus Candida krusei, Candida albicans, and Candida parapsilosis C. glabrata HO5 was assessed