A series of thiourea derivatives have been synthesized. Thiourea derivatives show a broad spectrum of biological activities such as antibacterial, antiviral, anticancer, anticonvulsion, analgesic an HDL-elevating. Ethyl isothiocyanate and aromatic amines were mixed and stirred at room temperature in acetone for 15 h to give the corresponding thioureas in high yields. Their structures were confirmed by IR and 1H-NMR. By addition e-donor groups to aromatic amines, thioureas were synthesized in high yields