In this investigation, the chemical synthesis and physicochemical categorization of synthesized ligands (L1–L3) have been successfully designed and derived from substituted 4-amino-5-mercapto-1, 2, 4-triazole using various substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehyde and resultant Ni (II) complexes (C1–C3) have been described. The structures of synthesized ligand and the resultant complexes were inspected using UV-Vis spectroscopy, thermo gravimetric analysis, Fourier transform infrared spectroscopy and 1H NMR. The consequential data revealed octahedral geometry for the resultant complexes. The novel nickel complexes have been ascertained as potential antimicrobial and antioxidant agents