In this study, the novel azo-dye 4-[(E)-(2-nitrophenyl)diazenyl]-1,3-thiazol-amine (NTA/C9H7N5O2S) and its coordinated metal salts [Co(NTA)2.(H2O)2] and [Ni(NTA)2.(H2O)2] were synthesized. Further, geometry and its physico-chemical character of the compounds characterised via FT-IR, elemental analysis, UV-Vis, mass spectra, 1HNMR and thermogravimetric spectral analysis; the all spectral data suggested tetrahedral geometry for synthesised Co (II) and Ni (II) complexes along with PXRD evidence. Ligand and its [Co(NTA)2.(H2O)2] and [Ni(NTA)2.(H2O)2] compounds were tested against in-vitro antioxidant properties. The [Co(NTA)2.(H2O)2] act as a good antioxidant agent. In this connection, we designed a new efficient drug performance in biological properties and actively participates against foreign diseases in body.