Bruxism, a condition that can be primary as in with no pre-medical complications, or secondary due to psychiatric medication or neurological disorder such as Parkinson’s and Huntington’s diseases. It involves a steady clenching of the teeth, grinding and or combination of both. Bruxism is an universal hurdle amongst clinicians as its abnormal parafunctional activity when ignored leads to masticatory muscle hypertrophy, tooth surface loss, fracture of restorations, hypersensitivity and oro-facial pain. This article gives a brief review on bruxism associated with systemic conditions with literature concerning the etiology of the oral habit, clinical manifestations and current treatment approaches of bruxism like occlusal therapy, behaviour modification, Biofeedback and pharmacological therapy.