Introduction: Taurine has proved to be involved in a wide range of biological processes and provides several different important health benefits. Its effects have been revealed to be exerted mainly through its antioxidant, osmoregulation and anti-inflammatory effects, among other mechanisms. Objectives and methods: The present review is aimed to provide a solid body of evidence regarding the beneficial effects of taurine in the context of glucose metabolism in diabetes and its complications, with an special focus on the blood glucose level, cardiovascular health impairments so frequently associated to this disease, so that data from this updated systematic review of the literature, may constitute a base to back up future clinical and epidemiological studies, on the possibilities of taurine supplementation as a useful tool for both prevention and treatment of diabetes complications. Conclusions: We consider results from the different experimental, in vitro studies as well as some clinical ones reviewed, to provide sufficient evidence as to constitute a solid base to back up future clinical and epidemiological studies on the usefulness of taurine supplementation both in the prevention and treatment of diabetes and its complications with effect on glucose metabolism and level in the blood.