In the field of pediatric gastroenterology, upper gastrointestinal endoscopy has established itself as a diagnostic and therapeutic tool. In order to increase patient tolerance during this procedure, deep sedation is essential. Children are at a higher risk of serious adverse effects from procedural sedation; thus, their safety is a primary issue throughout this procedure. The agent of choice for procedural sedation should be safe, provide adequate analgesia and sedation with quick onset and short duration to allow the performance of a procedure with quick recovery and discharge. Benzodiazepines, ketamine, propofol, ketamine with propofol, nitrous oxide, and etomidate are all well-studied agents in pediatric procedural sedation. Multiple studies have been done to find the ideal method for procedural sedation in terms of ease of administration, quality, safety of sedation and recovery profile, but the consensus seems lacking