The present study investigated the ability of a lab-scale sequencing-batch membrane bioreactor (SMBR) to remove antibiotics from cow wastewater. We evaluated three veterinary antibiotics from different families:sulfamethoxazole (SM), oxytetracycline (OT), and ciprofloxacin (CF). We found that the SMBR had a high capacity for removing SM (>90%) and OT(>88%), while its ability to remove CF was weaker (>60%). Mass balance analysis revealed that biodegradation is the primary pathway for antibiotic removal in the SMBR system, with sludge adsorption and membrane retention playing a minor role. It is worth noting that OT and CFexhibited higher accumulation in biosolids thanSM. Furthermore, the SMBR system effectively removed nutrients and organic matter from cow wastewater.