A novel procedure to design a hybrid intelligent Single Neuron PID controller (SNPID) for the continuous biochemical reactor has been proposed in this paper. High levels of nonlinearity are observed in the biochemical reactor process because of the continuous change of the fermentation process parameters. So, in order to attain high steady-state productivity, a strong hybrid PID controller is designed for the biochemical reactor. By regulating the (inlet) dilution rate, the proposed controller effectively controls the biomass concentration in the bioreactor at an unstable steady state. The proposed hybrid intelligent Single Neuron PID controller takes the closed loop error as the input and the dilution rate as its output. The closed loop performance of the SNPID controller is compared with that of a PID controller under disturbance conditions. Simulation results show that the proposed controller outperforms the PID in all cases.