This study aims to determine and analyze the influence of accounting information and information technology on business decision making of Micro, Small and Medium Enterprises (MSME) registered at the Koperindag Office of Asahan Regency. This research is a quantitative research. The population in this study were MSME registered at The Koperindag Office Of Asahan Regency as many as 13,572 MSME. The number of samples was calculated using the Slovin formula and obtained as many as 99 MSME engaged in the snack sector were selected using the Simple Random Sampling method. The data is analyzed using Descriptive Statistical Analysis and its data analysis by using the Eviews software program. The results of this study show that: (1) Accounting Information has a positive and significant effect on business decision making on the decision makingof micro, small and medium enterprise (MSME) registered with the Koperindag Office of Asahan Regency; (2) Information technology has a significant positive effect on business decision making on the decision makingof micro, small and medium enterprise (MSME) registered with the Koperindag Office of Asahan Regency