peptic ulcer disease (PUD) is known as an inflammation or excavations in the mucous membrane and tissues of the intestinal tract. Al-Jouri rose (damascene Rosa) is an ornamental plant and beside perfuming effect, several pharmacological properties including antioxidant and Anti-inflammatory .The present study was conducted to investigate the effects of al-Jouri rose on stomach ulcers in experimental rats . thirty-five male albino rats were divided into five groups: group I and group II were kept as negative and positive control rats (Indomethacin-treated rats), respectively, and were fed on the normal basal diet. While the other remaining three groups treated with three levels of damascene Rosa (15%, 20% and 30%) and were fed on the normal basal diet respectively for 4 weeks. At the end of the experimental period, antioxidant enzymes, liver function and kidney function were determined for all studied groups. Results revealed that Indomethacin-treated rats and fed on different levels of damascene Rosa had significantly decreased (p < 0.05) in serum levels of (AST, ALT, ALP, Urea , Creatinne , Uric acid, SOD, GSH and CAT). While, there was a significant increase in level of MDA as compared to Indomethacin-treated rats (positive control group). In addition, pathological examination of the stomach tissues that oral treatment with damascene Rosa at three levels showed significant reduction of gastric ulcer area. Finally, the obtained results proved that Rosa damascene improve of deterioration resulting from gastric ulcer disease